The Kaguya clan (かぐや一族, Kaguya Ichizoku) is an extinct clan known to have been very barbaric. Select few; namely Kimimaro possess the Kekkei Genkai Shikotsumyaku.

The clan was killed off when attacking Kirigakure; except Kimimaro, who ran away. The clan was also very savage and had no tactics when going to battle. Kimimaro then joined with Orochimaru who planed to steal his body, but Kimimaro developed a disease. He was eventually killed by his own illness.